Is Bound Water a Surrogate for Collagen Matrix Density? Insights from 1H Zero Echo-Time MRI
Alan C. Seifert 1 , Suzanne L. Wehrli 2 , Henry H. Ong 1 , and Felix W. Wehrli 1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
Core Facility, Children's Hospital of Philadelphia,
Philadelphia, PA, United States
The very shortest-T2 (~20-50 s) component of bone 1H
signal arises from the collagen backbone of bone matrix.
We present images of bone matrix collagen from lamb
tibial cortical bone (fully D2O-exchanged, air-dried to
remove pore water, and fully H2O-hydrated) at 9.4T using
a zero echo-time sequence. NMR spectroscopy confirms the
removal of the narrow-line signal from the D2O-exchanged
bone, and presence of the collagen-associated 40-kHz
splitting in all three bones. Although collagen 1H
signal is visible at 9.4T with 245-mT/m gradients, this
signal may still be beyond the reach of clinical
scanners with more limited gradient strengths.
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