Abstract #3992
Bone Mineral and Matrix Densities Measured by Solid-State 1H and 31P MRI
Alan C. Seifert 1 , Cheng Li 1 , Chamith S. Rajapakse 1 , Mahdieh Bashoor-Zadeh 1 , Yusuf A. Bhagat 1 , Alexander C. Wright 1 , Babette Zemel 2 , Antonios Zavaliangos 3 , and Felix W. Wehrli 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
GI,
Hepatology, and Nutrition, Children's Hospital of
Philadelphia, Philadelphia, PA, United States,
3
Materials
Science and Engineering, Drexel University,
Philadelphia, PA, United States
Osteoporosis and osteomalacia both manifest as reduced
apparent bone mineral density. The differentiating
factor is mineral per volume of matrix. Advances in
solid-state MRI have led to the possibility of
quantitative bone mineral 31P and collagen-bound water
1H density measurement. Sixteen fully-mineralized human
bone specimens were scanned with 31P ZTE and 1H
Adiabatic Inversion-Recovery ZTE, and 31P and bound
water densities were quantified relative to reference
phantoms. Both densities correlate negatively with age
and porosity, and positively with pQCT density, and as
expected, the ratio of 31P to bound water density does
not correlate with age, porosity, or pQCT density.
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