Cross-relaxation parameters in cortical bone from combined VFA-UTE and off-resonance saturation

Cortical bone porosity can be determined by UTE-MRI. Magnetization Transfer has been already observed between collagen-bound water and free water. Since porosity depends on T1 value, the method used for T1 measurement should be critically assessed. T1 values deduced from UTE experiments at different TR and flip angles in bovine cortical bone increased with TR. Cross-relaxation parameters in agreement with an off-resonance experiment with a long saturation pulse allowed us to simulate the TR-dependent effect of the variable flip angle (VFA) acquisition. The uncertainty on the two-pool parameters was lower when simulating VFA experiment than when fitting off-resonance saturation.

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