Cross-relaxation parameters in cortical bone from combined VFA-UTE and off-resonance saturation
Khaoula Bouazizi-Verdier 1 and Genevive Guillot 1
IR4M - UMR8081 - CNRS - Univ. Paris Sud,
Cortical bone porosity can be determined by UTE-MRI.
Magnetization Transfer has been already observed between
collagen-bound water and free water. Since porosity
depends on T1 value, the method used for T1 measurement
should be critically assessed. T1 values deduced from
UTE experiments at different TR and flip angles in
bovine cortical bone increased with TR. Cross-relaxation
parameters in agreement with an off-resonance experiment
with a long saturation pulse allowed us to simulate the
TR-dependent effect of the variable flip angle (VFA)
acquisition. The uncertainty on the two-pool parameters
was lower when simulating VFA experiment than when
fitting off-resonance saturation.
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