Abstract #4001
Intervertebral disc degeneration and changes in solute transport mechanisms in disc endplates studied by DCE-MRI
L.Tugan Muftuler 1 , Joshua J. Jarman 2 , Hon J. Yu 3 , Dennis J. Maiman 4 , and Vance O. Gardner 5
1
Department of Neurosurgery and Center for
Imaging Research, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Medical
college of Wisconsin, WI, United States,
3
Radiological
Sciences, University of California, Irvine, CA, United
States,
4
Department
of Neurosurgery, Medical college of Wisconsin,
Milwaukee, WI, United States,
5
Orthopedic
Research Institute of California, CA, United States
Disruption of nutrient delivery through the endplates of
intervertebral discs could be a factor initiating or
accelerating the degeneration processes. Thus, our goal
was to develop a high spatial resolution Dynamic
Contrast Enhanced MRI (DCE-MRI) protocol to study solute
transport mechanisms in the cartilaginous endplates and
subchondral bone of degenerating discs. Results indicate
that the cracks and fissures developing in the
subchondral bone of degenerating discs lead to increased
DCE-MRI enhancement. Furthermore, caudal endplates
showed higher enhancement than cranial endplates and the
difference increased at lower lumbar levels.
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