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Abstract #4004

Tracking Disease Progression in Duchenne Muscular Dystrophy: Longitudinal Changes in Quantitative MR Measures

William D. Rooney 1 , Sean C. Forbes 2 , William T. Triplett 3 , James R. Pollaro 1 , Dah-Jyuu Wang 4 , Soren deVos 2 , James Meyer 4 , Rebecca Willcocks 3 , Barry Byrne 5 , Richard Finkel 6 , Barry Russman 7 , Erika Finanger 7 , Michael Daniels 8 , Lee Sweeney 9 , Glenn Walter 3 , and Krista Vandenborne 2

1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon, United States, 2 Department of Physical Therapy, University of Florida, Gainesville, Florida, United States, 3 University of Florida, Physiology and Functional Genomics, Gainesville, Florida, United States, 4 Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 5 Department of Pediatrics, University of Florida, Gainesville, Florida, United States, 6 Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 7 Shriners Hospital, Portland, Oregon, United States, 8 University of Texas, Austin, Texas, United States, 9 Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States

This study investigates the utility of quantitative MR measures to track disease progression in DMD. 3T Data were acquired from 125 DMD and 28 control boys. 1 H MRS data were acquired to estimate fat fraction (FF) in vastus lateralis (VL) and soleus (Sol) muscles. MRI quantitative T 2 (qT 2 ) values were determined for muscles in the upper and lower leg. DMD boys were studied at baseline, and 12 month and 24 month follow-ups. Both FF and qT 2 are increased at follow-up with greatest absolute differences found in upper leg muscles. MRI qT 2 values were strongly associated with muscle FF.

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