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Abstract #4013

Whole-body Dixon for skeletal muscle fat fraction quantification in neuromuscular disorders

Benjamin Marty 1 , Pierre-Yves Baudin 1 , Benjamin Robert 2 , Alexey Shukelovich 1 , Robert-Yves Carlier 3 , Noura Azzabou 1 , and Pierre G Carlier 1

1 AIM-CEA Institut de Myologie, Laboratoire RMN, Paris, France, 2 Siemens Healthcare, Saint-Denis, France, 3 AP-HP Hpital Universitaire Raymond-Poincar, Garches, France

Fatty infiltration of muscles is a marker of disease progression in muscular dystrophies. Although routine T1-weighted imaging gives an indication of the presence or absence of muscular fat infiltration, it is difficult to extract quantitative data from these images. On the contrary, Dixon methods can give quantitative measures of water and fat fractions. Generally, whole-body exams consist in the acquisition of a T1w sequence, followed by Dixon acquisitions on targeted regions to quantitatively assess fat infiltration. In our study we demonstrate that the use of a well calibrated sequence allows replacing whole-body T1w imaging by a whole-body Dixon imaging.

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