Multimodal fitting of diffusion MRI data for assessing the inflammatory/microvascularity relationship in a glioma rat model
Blanca Lizarbe 1 , Ana Amor-Lpez 1 , Sebastin Cerdn 1 , and Pilar Lpez-Larrubia 1
Instituto Investigaciones Biomdicas
"Alberto Sols" CSIC-UAM, Madrid, Madrid, Spain
Brain tumors are associated with tissue inflammation and
microvasculature alterations that are MRI detectable.
DWI and PWI techniques have been widely used to provide
information about blood flow/volume, edema and
cellularity. Nevertheless, a better understanding of the
relationship between inflammation and microvascular
changes during tumoral growth needs to be established.
In this work, we present a multimodal evaluation of
gliobastoma growth in rat brains using DWI with high and
low b-weightings, and three models of diffusion with or
without perfusion effects- fitting. Our results indicate
lower water diffusion behavior but higher perfusion
contributions in the early stages of tumor growth.
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