Multimodal fitting of diffusion MRI data for assessing the inflammatory/microvascularity relationship in a glioma rat model

Brain tumors are associated with tissue inflammation and microvasculature alterations that are MRI detectable. DWI and PWI techniques have been widely used to provide information about blood flow/volume, edema and cellularity. Nevertheless, a better understanding of the relationship between inflammation and microvascular changes during tumoral growth needs to be established. In this work, we present a multimodal evaluation of gliobastoma growth in rat brains using DWI with high and low b-weightings, and three models of diffusion with or without perfusion effects- fitting. Our results indicate lower water diffusion behavior but higher perfusion contributions in the early stages of tumor growth.

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