Abstract #4041
Separation and Quantitative Assessment of Mobile Lipid and Lactate Level by Diffusion Weighted Magnetic Resonance Spectroscopy (DW-MRS)
Anna M. WANG 1,2 , Karrie Mei-Yee Kiang 3 , GK Leung 3 , Adrian Tsang 1,2 , Victor B. Xie 1,2 , Hua Guo 4 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong, Hong
Kong,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong,
3
Department
of Surgery, The University of Hong Kong, Hong Kong, Hong
Kong,
4
Center for Biomedical Imaging Research,
School of Medicine, Tsinghua University, China
This study explored the capability of Diffusion Weighted
Magnetic Resonance Spectroscopy (DW-MRS) for the
separation and quantification of the overlapped mobile
lipid and lactate signal at 1.3ppm. Both the content and
ADC value can be computed from fitting the diffusion
weighted signal to a bi-exponential decay model. In this
rat model of intracerebral C6 glioma, the spectra from
the tumor region was dominated by the mobile lipid
signal and the lipid signal intensity is approximately
ten times higher than the lactate signal. Our result
also shows the lactate ADC in C6 glioma is
2.9(0.9)104 mm2/s and the lipid ADC is 3.3(1.3)104
mm2/s. Demonstrated by this study, the DW-MRS provides a
feasible way to solve the overlapping problem of the
lactate and mobile lipid peak at 1.3ppm, giving an
alternative method for the quantification of lipid and
lactate content in the clinical study.
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