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Abstract #4050

Acquired resistance to EGFR tyrosine kinase inhibitors in human head and neck squamous carcinoma cells (HNSCC) and xenografts is associated with an altered metabolic phenotype

Mounia Beloueche-Babari 1 , Carol Box 2 , Harry G Parkes 1 , Melanie Valenti 2 , Alexis De Haven Brandon2 2 , Liz Jackson 1 , Vaitha Arunan 1 , Sue Eccles 2 , and Martin O Leach 1

1 CRUK & EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 CRUK Cancer Therapeutics Unit, Institute of Cancer Research, Sutton, Surrey, United Kingdom

Acquired resistance to molecular therapeutics, including tyrosine kinase inhibitors (TKIs), is a key challenge in personalized cancer medicine. Identifying mechanisms and biomarkers of resistance could help detect patient relapse early and improve disease management. Here we show that acquired resistance to multiple epidermal growth factor receptor (EGFR) TKIs in human head and neck squamous cell carcinoma is associated with altered glycolytic, choline phospholipid and amino acid metabolism as detected by 1H MRS of cell line and xenograft tumor extracts. Such effects could provide potential metabolic imaging biomarkers of acquired resistance to EGFR TKIs

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