Abstract #4073
AMESING and BINEPT 31P MRS at 7T distinguishes glycerophosphatidylcholine from glycerophosphocholine
Wybe JM van der Kemp 1 , Bertine L Stehouwer 1 , Jurgen H Runge 2 , Jannie P Wijnen 1 , Aart J Nederveen 2 , Peter R Luijten 1 , and Dennis WJ Klomp 1
1
Radiology, UMC Utrecht, Utrecht,
Netherlands,
2
Radiology,
AMC, Amsterdam, Netherlands
The ratio between phosphocholine (PC),
phosphoethanolamine (PE) and their glycerol compounds
(GPE and GPC) are highly valuable biomarkers. However,
when obtained in vivo, these signals can overlap with
signals from membrane phospholipids (i.e.
glycerophosphatidyl-choline (GPtC) and ethanolamine
(GPtE)). Using adiabatic multi-echo (AMESING) and
polarization transfer (BINEPT) techniques at 7T we
demonstrate that based on chemical shift, absence of
polarization transfer and reduced T2, the majority of
phosphodiester signals obtained in breast tissue
originate from GPtC and GPtE rather than from the GPE
and GPC.
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