The Role of Multiparametric MRI in Contemporary Radiotherapy of Prostate Cancer

Three clinical trials are initiated for targeted radiation treatment of prostate cancer, based on the hypothesis that: (i) the dominant lesions recognized on multiparametric MRI (MP-MRI) determine outcome; (ii) MP-MRI-directed biopsies are critical to accurately assessing pre-treatment (pre-Tx) histopathologic and molecular characteristics; (iii) MP-MRI parameters are related to tumor response and molecular abnormalities; (iv) early MP-MRI changes after treatment will correlate with response and (v) targeting these lesions will improve control rates without increasing toxicity. The workflow for integration of MP-MRI at multiple points in the trails design is discussed, together with preliminary results.

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