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Abstract #4115

Role of Hypoxia in Aggressive Prostate Cancer A Hyperpolarized 13C MR Study

Renuka Sriram 1 , Kayvan R Keshari 2 , Robert Bok 1 , Subramaniam Sukumar 1 , Mark Van Criekinge 1 , Daniel B Vigneron 1 , and John Kurhanewicz 1

1 University of California, San Francisco, San Francisco, California, United States, 2 Memorial Sloan-Kettering Cancer Center, New York, United States

This study demonstrates that hypoxia is significantly increased in TRAMP tumors, and is responsible for driving metabolic and micro-environmental changes that favor disease progression. Moreover, these metabolic and micro-environmental changes can be imaged using a multi-probe hyper polarized 13 C MRI approach. The increase in the hyperpolarized 13 C signals of Lac/Pyr ratio as well as urea in late stage compared to early stage tumors is synchronized with the increased expression of hypoxic gene regulators. These pre-clinical findings recapitulate the human situation where increasing levels of hypoxia have been measured with increasing clinical stage, and correlated with poor clinical outcomes.

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