Abstract #4115
Role of Hypoxia in Aggressive Prostate Cancer A Hyperpolarized 13C MR Study
Renuka Sriram 1 , Kayvan R Keshari 2 , Robert Bok 1 , Subramaniam Sukumar 1 , Mark Van Criekinge 1 , Daniel B Vigneron 1 , and John Kurhanewicz 1
1
University of California, San Francisco, San
Francisco, California, United States,
2
Memorial
Sloan-Kettering Cancer Center, New York, United States
This study demonstrates that hypoxia is significantly
increased in TRAMP tumors, and is responsible for
driving metabolic and micro-environmental changes that
favor disease progression. Moreover, these metabolic and
micro-environmental changes can be imaged using a
multi-probe hyper polarized
13
C
MRI approach. The increase in the hyperpolarized
13
C
signals of Lac/Pyr ratio as well as urea in late stage
compared to early stage tumors is synchronized with the
increased expression of hypoxic gene regulators. These
pre-clinical findings recapitulate the human situation
where increasing levels of hypoxia have been measured
with increasing clinical stage, and correlated with poor
clinical outcomes.
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