Reproducibility of Resting-State fMRI Data in Rats across Three Months

Resting-state fMRI of animal models has the advantage to assess the trajectory of a disease using longitudinal paradigms, but the reproducibility of the observations is critical and less known. Here, we investigate the reliability of resting fMRI signal of rats in short (10 min), middle (2 weeks) and long (3 months) terms. Our data showed that the mean ICC across brain networks during short- or mid-term scans (0.63 and 0.57 respectively) was significantly higher than that of long-term scans (0.22), suggesting that longitudinal experiments within weeks would have good reproducibility, but studies across months should be practiced with caution under the current conditions.

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