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Abstract #4147

Variability in activated volume using canonical HRF or individual HRF

Mariela Hidalgo 1 , Juan Vielma 2 , Rodrigo Salas 1 , Alejandro Veloz 1,3 , and Steren Chabert 1

1 Biomedical Engineering Department, Universidad de Valparaso, Valparaso, Quinta Region, Chile, 2 Medicine Faculty, Universidad de Valparaso, Valparaso, Quinta Regin, Chile, 3 Informatics Department, Universidad Tcnica Federico Santa Mara, Valparaso, Quinta Regin, Chile

In many studies of functional MRI the existence of inter individual variability in the hemodynamic response function has been demonstrated and influences the cortical activation detection. This study consists in evaluating this effect among seven healthy volunteers when an individual HRF is used in the detection of brain activation in the general lineal model analysis. In about half of the cases, similar activation volumes are detected in both cases. Our data show low variability in Time-To-Peak, with a mean TTP longer than the canonical TTP. A robust methodology is still to be defined to reduce possible the inter-individual volume variability.

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