Abstract #4147
Variability in activated volume using canonical HRF or individual HRF
Mariela Hidalgo 1 , Juan Vielma 2 , Rodrigo Salas 1 , Alejandro Veloz 1,3 , and Steren Chabert 1
1
Biomedical Engineering Department,
Universidad de Valparaso, Valparaso, Quinta Region,
Chile,
2
Medicine
Faculty, Universidad de Valparaso, Valparaso, Quinta
Regin, Chile,
3
Informatics
Department, Universidad Tcnica Federico Santa Mara,
Valparaso, Quinta Regin, Chile
In many studies of functional MRI the existence of inter
individual variability in the hemodynamic response
function has been demonstrated and influences the
cortical activation detection. This study consists in
evaluating this effect among seven healthy volunteers
when an individual HRF is used in the detection of brain
activation in the general lineal model analysis. In
about half of the cases, similar activation volumes are
detected in both cases. Our data show low variability in
Time-To-Peak, with a mean TTP longer than the canonical
TTP. A robust methodology is still to be defined to
reduce possible the inter-individual volume variability.
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