Longitudinal functional connectivity changes in mild traumatic brain injury: correlation with diffusion, T2 and behavioral outcomes

This study examined longitudinally the rsfMRI changes in mild TBI of the (unilateral) primary somatosensory cortex in rats during hyperacute and chronic phase up to 14 days. Quantitative correlations were made with T2, DTI, fractional anisotropy (FA), and functional outcomes (forelimb placement asymmetry and foot fault scores). rsfMRI z-scores reduced after mild TBI but improved with time. The trend of improvement parallels those of behavioral scores. rsfMRI did not significantly correlate with ADC and FA changes, suggesting they provide complementary information. This study demonstrated that rsfMRI offers novel insights into functional connectivity in mild TBI.

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