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Abstract #4158

Recording BOLD, ASL and CBV fMRI responses to epileptic spikes in rats

Sandrine Saillet 1,2 , Olivier David 1,2 , and Jan M. Warnking 1,2

1 U836, Inserm, Grenoble, France, 2 Grenoble Institut des Neurosciences, Universit Joseph Fourier, Grenoble, France

Recording EEG together with fMRI has permitted to unravel the neuronal correlates of spontaneous brain activity. However the mechanisms involved in the coupling between epileptic discharges (EDs) and the hemodynamic response are partially known. Actually, the interpretation of fMRI results (activated or deactivated), in terms of underlying physiological processes crucially depend on the understanding of these mechanisms. In this work, we measured local field potentials simultaneously with changes in BOLD signal, cerebral blood flow (via ASL) and cerebral blood volume (via Mion fMRI) in the rat somatosensory cortex following intracortical bicuculline injection eliciting interictal-like discharges.

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