Increased gray matter density in parallel with increased connectivity in Parkinson disease
Mihaela Onu 1 , Liviu Badea 2 , and Adina Roceanu 3
Medical Imaging, Clinical Hospital "Prof.
dr. Th. Burghele", Bucharest, Romania,
Institute for Research in Informatics, Bucharest,
University Emergency Hospital
Bucharest, Bucharest, Romania, Romania
We hypothesized that, in Parkinson disease (PD), gray
matter density and functional cerebral connectivity
might develop compensatory behaviors in response to the
damaged motor control loops. Using VBM and rsfmri
analyses, we found a gray matter thalamic enlargement in
parallel with increased connectivity at the basal
ganglia/thalamic level which may reflect a compensatory
effect in response to the damaged motor control loops.
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