Abstract #4199
Inter-regional Differences in Brain Response Delay to End-Tidal CO2 Estimated from Resting-State fMRI
Ali M Golestani 1,2 and J Jean Chen 1,2
1
Rotman Research Institute, Baycrest,
Toronto, ON, Canada,
2
University
of Toronto, Toronto, ON, Canada
End-tidal CO2 (PETCO2) drives the BOLD signal. This
effect is not homogeneous across brain regions, and
delay maps are estimated using breath holding or other
respiratory tasks, which could be uncomfortable for
subjects. We investigated regional variability of PETCO2
effect by estimating the response of the resting-state
BOLD signal to PETCO2 fluctuations with high temporal
resolution (TR = 0.323S). We estimated the PETCO2
response at each voxel and computed the time to peak (TTP)
of estimated response for multiple brain region We show
that it is possible to assess brain hemodynamics using
resting-state BOLD TTP in response to PETCO2.
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