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Abstract #4215

Cerebral Blood Volume Contribution to the Functional T1ρ in the Human Brain

Hye-Young Heo 1 , Casey P Johnson 1 , Daniel R Thedens 1 , John A Wemmie 2,3 , and Vincent A Magnotta 1,3

1 Department of Radiology, University of Iowa, Iowa City, Iowa, United States, 2 Department of Neurosurgery, University of Iowa, Iowa, United States, 3 Department of Psychiatry, University of Iowa, Iowa, United States

Recent experiments suggest that functional imaging of T1 relaxation in the rotating frame (T1ρ) can detect localized metabolic changes in the human visual cortex induced by a flashing checkerboard task. Possible sources of the functional T1ρ signal include changes in pH, glucose and glutamate concentrations, and cerebral blood volume. In this study we explored the relationship between the functional T1ρ signal and cerebral blood volume by employing an inferior saturation pulse. The results show that, although there is a contribution of cerebral blood volume to the functional T1ρ signal, a majority of the signal likely comes from the tissue compartment. Therefore, using spatial saturation pulses is an effective and efficient means to minimize blood volume contributions to the functional T1ρ signal.

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