Abstract #4235
Specificity of the Inhomogeneous Magnetization Transfer Approach to Myelinated Tissues
Novena A Rangwala 1 , Gopal Varma 1 , Olivier Girard 2 , Guillaume Duhamel 2 , David B Hackney 1 , and David C Alsop 1
1
Department of Radiology, Beth Israel
Deaconess Medical Center and Harvard Medical School,
Boston, Massachusetts, United States,
2
CRMBM
UMR 7339, CNRS / Aix-Marseille UniversiteĢ, Marseille,
France
The inhomogeneous magnetization transfer (IHMT) approach
generates images both sensitive and specific to
myelinated tissues, especially white matter (WM). We
investigated the specificity of IHMT to several tissues
and organs not containing myelin. IHMT images were
acquired in cervical and thoracic spine and in the
abdomen; and IHMT ratios (IHMTR) were compared with MT
ratios (MTR) in these tissues. Results showed MTR of
6-27% in different tissues, with MTR ~ 23% in WM. In
contrast, IHMTR demonstrated specificity to
myelin-containing tissues with 5% in WM, < 2% in gray
matter and virtually no IHMTR in other investigated
tissues. IHMT may be a reliable marker for myelin in the
investigation of WM disorders.
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