Abstract #4237
Magnetization Transfer from Inhomogeneously Broadened Lines (ihMT): Sequence Optimization
Olivier M. Girard 1 , Valentin Prevost 1 , Gopal Varma 2 , David C. Alsop 2 , and Guillaume Duhamel 1
1
CRMBM UMR 7339, CNRS / Aix-Marseille
Universit, Marseille, France,
2
Radiology
Department, Beth Israel Deaconess Medical Center and
Harvard Medical School, Boston, MA, United States
Inhomogeneous magnetization transfer (ihMT) imaging has
been proposed as a new method for imaging myelinated
tissues of the central nervous system. Previous studies
have shown promising results on both humans and small
animals, at various magnetic field strengths. Various
sequence parameters were used and a better understanding
of the contrast mechanisms is necessary to further
optimize the ihMT effect. Here we characterize the ihMT
contrast with respect to the main sequence parameters of
a pulsed ihMT preparation module at 1.5T. Very useful
information can be derived from presented results in
order to optimize ihMT signal and contrast.
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