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Abstract #4241

Methods for Myelin Water Imaging

Eva Alonso Ortiz 1 and Gilbert Bruce Pike 2

1 Department of Physics, Medical Physics Unit, McGill University, Montreal, QC, Canada, 2 Department of Radiology and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

Multi-component T2 relaxation time measurement in the central nervous system shows a component that originates from water trapped in the lipid bilayers of myelin. This myelin-water component is of significant interest as it provides a myelin specific MRI signal of value in assessing myelin changes in cerebral white matter in vivo. In this educational e-poster the various acquisition and analysis strategies proposed to date for myelin water imaging are reviewed and research conducted into their validity and clinical applicability is presented. Comparisons between the imaging methods are made with a discussion regarding potential difficulties and model limitations.

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