Abstract #4241
Methods for Myelin Water Imaging
Eva Alonso Ortiz 1 and Gilbert Bruce Pike 2
1
Department of Physics, Medical Physics Unit,
McGill University, Montreal, QC, Canada,
2
Department
of Radiology and Hotchkiss Brain Institute, University
of Calgary, Calgary, Alberta, Canada
Multi-component T2 relaxation time measurement in the
central nervous system shows a component that originates
from water trapped in the lipid bilayers of myelin. This
myelin-water component is of significant interest as it
provides a myelin specific MRI signal of value in
assessing myelin changes in cerebral white matter in
vivo. In this educational e-poster the various
acquisition and analysis strategies proposed to date for
myelin water imaging are reviewed and research conducted
into their validity and clinical applicability is
presented. Comparisons between the imaging methods are
made with a discussion regarding potential difficulties
and model limitations.
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