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Abstract #4269

Comparison of MR elastography inversion methods on high-resolution measurements in the human brain

Ruth J. Okamoto 1 , Curtis L. Johnson 2 , Matthew D. McGarry 3 , Andrew A. Badachhape 4 , Bradley P. Sutton 2 , John G. Georgiadis 2 , and Philip V. Bayly 1

1 Mechanical Engineering and Materials Science, Washington University, Saint Louis, Missouri, United States, 2 Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Illinois, United States, 3 Dartmouth College, Hanover, New Hampshire, United States, 4 Biomedical Engineering, Washington University, Saint Louis, Missouri, United States

Three approaches, local frequency estimation (LFE), local direct inversion (LDI), and nonlinear inversion (NLI), were used to estimate viscoelastic parameters of the human brain from high-resolution magnetic resonance elastography (MRE) measurements. While each inversion method has been independently validated using gel phantoms, the complicated structure of the human head (comprising skull, meninges, CSF, and brain) and the complex material behavior of the brain (anisotropic, heterogeneous, and poroelastic) challenge the underlying assumptions of each method. Differences were found between average shear modulus estimates obtained by the three methods (NLI>LFE>LDI), however the relative differences between individuals were consistent among all methods.

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