Abstract #4269
Comparison of MR elastography inversion methods on high-resolution measurements in the human brain
Ruth J. Okamoto 1 , Curtis L. Johnson 2 , Matthew D. McGarry 3 , Andrew A. Badachhape 4 , Bradley P. Sutton 2 , John G. Georgiadis 2 , and Philip V. Bayly 1
1
Mechanical Engineering and Materials
Science, Washington University, Saint Louis, Missouri,
United States,
2
Beckman
Institute for Advanced Science and Technology,
University of Illinois, Urbana-Champaign, Illinois,
United States,
3
Dartmouth
College, Hanover, New Hampshire, United States,
4
Biomedical
Engineering, Washington University, Saint Louis,
Missouri, United States
Three approaches, local frequency estimation (LFE),
local direct inversion (LDI), and nonlinear inversion (NLI),
were used to estimate viscoelastic parameters of the
human brain from high-resolution magnetic resonance
elastography (MRE) measurements. While each inversion
method has been independently validated using gel
phantoms, the complicated structure of the human head
(comprising skull, meninges, CSF, and brain) and the
complex material behavior of the brain (anisotropic,
heterogeneous, and poroelastic) challenge the underlying
assumptions of each method. Differences were found
between average shear modulus estimates obtained by the
three methods (NLI>LFE>LDI), however the relative
differences between individuals were consistent among
all methods.
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