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Abstract #4276

On the need for T2* correction in quantitative water-fat imaging of skeletal muscle

Dimitrios C Karampinos 1 , Stefan Ruschke 1 , Holger Eggers 2 , Marcus Settles 1 , Hendrik Kooijman 3 , Peter Brnert 2 , Ernst J Rummeny 1 , and Thomas Baum 1

1 Department of Diagnostic and Interventional Radiology, Technische Universitt Mnchen, Munich, Germany, 2 Philips Research Laboratory, Hamburg, Germany, 3 Philips Healthcare, Hamburg, Germany

It is known that T 2 * decay effects can induce significant bias in the estimation of the fat fraction using a chemical shift based water-fat separation methods, especially in the presence of short T 2 *. However, the need for T 2 * correction has not been previously characterized in skeletal muscle fat quantification, where T 2 * decay is moderate but susceptibility-induced fat resonance shift effects are also present. The present study shows the existence of a synergistic effect between T 2 * decay and susceptibility shift on the estimation of the fat fraction. Single T 2 * correction reduces fat fraction bias due to the synergistic effect of T 2 * decay and susceptibility shift, independent of the choice of TEs.

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