Simultaneous Quantification of T1, T2, Fat Fraction and Off Resonance Frequency Using Phase Sweep SSFP

A new approach for simultaneous quantification of water T1 and T2, fat fraction (FF) and off-resonance frequency is proposed using a saturation-recovery prepared phase sweep SSFP method. The signal intensity profile in each pixel, as a function of RF phase increment (conventional SSPF has a constant 180 increment), is fit as a weighted sum of simulated fat and water basis sets (Bloch equations) to derive T1, T2, FF and off-resonance. This method was validated with Monte Carlo simulations (to characterize accuracy and precession), T1/T2 and fat phantoms, and in-vivo with characterization of tibialis, gastroc and soleus skeletal muscle groups

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