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Abstract #4305

AUTOMATED BRAIN EXTRACTION IN FETAL MRI BY MULTI-ATLAS FUSION STRATEGY: STUDY ON HEALTHY AND PATHOLOGICAL SUBJECTS.

Sbastien Tourbier 1,2 , Xavier Bresson 1,2 , Patric Hagmann 2 , Maud Cagneaux 3 , Marie Schaer 4 , Laurent Guibaud 3 , Jean-Philippe Thiran 2,5 , Reto Meuli 2 , and Meritxell Bach Cuadra 1,2

1 Centre d'Imagerie BioMdicale (CIBM), Lausanne, Vaud, Switzerland, 2 Department of Radiology, University Hospital Center (CHUV) and University of Lausanne, Lausanne, Vaud, Switzerland, 3 Department of Radiology, Hpital Femme-Mre-Enfant (HFME), Lyon, Rhne, France, 4 Department of Psychiatry, School of Medicine, University of Geneva, Geneva, Switzerland, 5 Signal Processing Laboratory (LTS5), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland

In fetal brain MRI, most of the high-resolution reconstruction algorithms rely on brain segmentation as a preprocessing step. Manual brain segmentation is highly time-consuming and therefore not a realistic solution for large-scale studies. Only few works have addressed this automatic extraction problem. In this study, we assess the validity of Multiple Atlas Fusion (MAF) strategies to automatically segment the fetal brain in MR imaging. We show that MAF performance is increased in healthy brain by increasing the number of atlases. Secondly, we also show that MAF can be applied to pathological brains even when large anatomical differences are present.

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