Abstract #4323
Novel upper airway compliance measurement using dynamic golden-angle radial FLASH
Ziyue Wu 1 , Yoon-chul Kim 2 , Michael C.K. Khoo 1 , and Krishna S. Nayak 2
1
Biomedical Engineering, University of
Southern California, Los Angeles, CA, United States,
2
Electrical
Engineering, University of Southern California, Los
Angeles, CA, United States
Obstructive sleep apnea (OSA) is a disease characterized
by repetitive upper airway (UA) narrowing or collapse
during sleep. Upper airway compliance, computed as the
change in UA cross-sectional area per unit pressure, is
a measure of airway collapsibility. Invasive fiberoptic
endoscopy has been previously used to measure the UA
area and compliance while recently MRI has been used as
an alternative noninvasive approach. Current 2D
cartesian MRI methods do not provide the spatio-temporal
resolution needed to fully resolve UA collapsing
dynamics during inspiratory load. We demonstrate the use
of dynamic golden-angle radial FLASH imaging in
combination with parallel imaging and compressed sensing
reconstruction to achieve 1mm spatial and 90ms temporal
resolution. From the results, UA dynamic changes can be
better visualized and compliance measurement is more
accurate with finer temporal and spatial resolution.
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