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Abstract #4359

Achieving 3D CINE from free breathing multi-slice 2D acquisitions via Simultaneous Groupwise Manifold Alignment

Muhammad Usman 1 , Christian Baumgartner 1 , Andrew King 1 , David Atkinson 2 , Tobias Schaeffter 1 , and Claudia Prieto 1,3

1 Division of Imaging Sciences and Biomedical Engineering, King's College London, London, Greater London, United Kingdom, 2 Department of Image Computing, University College London, London, United Kingdom, 3 Escuela de Ingenieria, Pontificia Universidad Catolica de Chile, Santiago, Chile

Multislice 2D CINE MRI is a common approach for assessing cardiac function and anatomy. This approach requires multiple breath-holds and usually suffers from slice-misalignments due to motion between the acquisitions. To overcome these problems, free-breathing respiratory-gated 3D CINE MRI have been proposed. However, these methods require long acquisition times and suffer from poorer contrast between blood and myocardium than 2D acquisitions1. In this work, we propose to combine the contrast of 2D acquisitions with the coverage of the 3D scans by generating a simulated 3D scan. This is achieved by addressing the issue of misalignment, which can occur between different slices in a multi-slice acquisition, using a self-gated Simultaneous Groupwise Manifold Alignment (SGA) technique. Prospective golden radial cardiac MR acquisitions, performed in 3 volunteers, demonstrate the feasibility of proposed framework to achieve gated simulated 3D CINE from free-breathing multi-slice 2D acquisitions.

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