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Abstract #4412

Probing the vitality of yeast suspensions by Double Diffusion Weighted MRI

Lars Mueller 1 , Andreas Wetscherek 1 , Jutta Janke 1 , Bram Stieltjes 2 , and Frederik Bernd Laun 1

1 Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 2 Quantitative Imaging-based Disease Characterization, German Cancer Research Center, Heidelberg, Germany

A double diffusion weighted sequence was implemented and tested on yeast suspension phantoms with different yeast concentrations. The sequence allowed us to determine the apparent exchange rate, which is a measure for water exchange rates across cell membranes, and the filter efficiency. Higher yeast concentrations result in lower exchange rates and higher filter efficiencies. Both parameters are dependent on the age of the yeast suspension and are shown to be good indicators of the vitality of the yeast suspension.

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