Meeting Banner
Abstract #4428

Methods for comparing fiber orientation distribution (FOD) functions based on histology and diffusion MRI

Yurui Gao 1 , Ann Choe 2 , Iwona Stepniewskwa 3 , Xia Li 2 , and Adam W Anderson 4

1 VUIIS, Vanderbilt University, Nashville, Tennessee, United States, 2 VUIIS, Vanderbilt University, TN, United States, 3 Psychology, Vanderbilt University, TN, United States, 4 BME, Vanderbilt University, TN, United States

In previous studies, we validated DTI-tractography-derived connectivity by comparing with the histological ground truth. Because DTI fiber orientation estimation is the basis of tractography, juxtaposing the DTI fiber orientation distribution (dFOD) and histological FOD (hFOD) is critical to validation studies. However, obtaining the 3D hFOD is challenging. This study introduces 1) two methods to extract the hFOD from z-stack micrographs and 2) the procedure to compare dFOD with hFOD functions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here