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Abstract #4430

Quantifying non-invasive MRI parameters with angiogenesis and cellular infiltration to characterize collagen-sponge remodeling

Mohammed Salman Shazeeb 1,2 , Sivakumar Kandasamy 2 , Stuart Howes 2 , and George Pins 2

1 Radiology, University of Massachusetts Medical School, Worcester, MA, United States, 2 Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, United States

Invivo evaluation of biomaterial implant remodeling involves surgical removal of the implant for subsequent histological assessment. This approach is often destructive and imposes practical limitations on how effectively these materials can be evaluated. MRI has the potential to non-invasively monitor the remodeling of collagen scaffolds. This study investigated the development of a model system to quantify MRI parameters with angiogenesis and cellular infiltration of implanted collagen scaffolds using MRI and histological techniques. Correlations between MRI and histological parameters demonstrated that MRI is sensitive to specific remodeling parameters which can aid in the design of robust biomaterial scaffolds for tissue regeneration.

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