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Abstract #4448

Clinically Feasible NODDI Characterization of Brain Tumor in 5.5 minutes Using Multiband EPI at 7T

Qiuting Wen 1,2 , Douglas A.C. Kelley 3 , Suchandrima Banerjee 4 , Janine M. Lupo 2 , Duan Xu 2 , Christopher P. Hess 2 , and Sarah J. Nelson 1,2

1 Graduate Program in Bioengineering, University of California, San Francisco & Berkeley, San Francisco, CA, United States, 2 Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 3 Global Applied Science Laboratory, GE healthcare, San Francisco, CA, United States, 4 Global Applied Science Laboratory, GE healthcare, Menlo Park, CA, United States

The goal of this study was to demonstrate the feasibility of acquiring 7T data suitable for NODDI in under 6 minutes with a tailored multiband technique for routine clinical application. In a brain tumor patient NODDI provided unique contrast within the T2 lesion. Although NODDI does not directly model tumor characteristics, it demonstrates great potential in revealing underlying tissue components that are complimentary to FA and ADC. With the multiband EPI technique, we reduced the acquisition time of this two-shell diffusion sequence to 5.5 minutes, making it clinically feasible. In addition to NODDI, both diffusion tensor and tractography data can also be generated from this protocol.

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