Abstract #4448
Clinically Feasible NODDI Characterization of Brain Tumor in 5.5 minutes Using Multiband EPI at 7T
Qiuting Wen 1,2 , Douglas A.C. Kelley 3 , Suchandrima Banerjee 4 , Janine M. Lupo 2 , Duan Xu 2 , Christopher P. Hess 2 , and Sarah J. Nelson 1,2
1
Graduate Program in Bioengineering,
University of California, San Francisco & Berkeley, San
Francisco, CA, United States,
2
Radiology
and Biomedical Imaging, University of California, San
Francisco, San Francisco, CA, United States,
3
Global
Applied Science Laboratory, GE healthcare, San
Francisco, CA, United States,
4
Global
Applied Science Laboratory, GE healthcare, Menlo Park,
CA, United States
The goal of this study was to demonstrate the
feasibility of acquiring 7T data suitable for NODDI in
under 6 minutes with a tailored multiband technique for
routine clinical application. In a brain tumor patient
NODDI provided unique contrast within the T2 lesion.
Although NODDI does not directly model tumor
characteristics, it demonstrates great potential in
revealing underlying tissue components that are
complimentary to FA and ADC. With the multiband EPI
technique, we reduced the acquisition time of this
two-shell diffusion sequence to 5.5 minutes, making it
clinically feasible. In addition to NODDI, both
diffusion tensor and tractography data can also be
generated from this protocol.
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