Abstract #4475
Human Brain Intravoxel Incoherent Motion (IVIM) : Optimized set-up for clinical investigation
Alberto Ciarmatori 1,2 , Elisa Cenacchi 1 , Tiziana Costi 1 , and Luca Nocetti 1
1
Medical Physics Department, University
Hospital "Policlinico", Modena, Italy,
2
Medical
Physics School, University "Alma Mater Studiorum",
Bologna, Italy
This study focused on separation of vascular and
non-vascular component of DWI signal decay. Brain scans
were performed using a 3T whole body MR on six healthy
volunteers. DWIs with multiple b-values
(0-5-10-20-30-40-50-75-100-150-200-300-500-1000 s/mm2)
were obtained. Datas were fitted with a biexponential
function with Diffusion Coefficient and Perfusion
Fraction obtained from high-b (>250 s/mm2)
monoexponential fit. A temporal optimized (6 min)
sequence was found . Significative differences were
observed D and standard ADC as well as between gray
matter and white matter diffusion parameters. In
particular D* of gray matter resulted significantly
greater than in white matter.
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