Abstract #4492
Improving fiber orientation estimation in constrained spherical deconvolution under non-white matter partial volume effects
Timo Roine 1 , Ben Jeurissen 1 , Wilfried Philips 2 , Alexander Leemans 3 , and Jan Sijbers 1
1
iMinds-Vision Lab, University of Antwerp,
Antwerp, Flanders, Belgium,
2
Department
of Telecommunications and Information Processing,
University of Ghent, Ghent, Flanders, Belgium,
3
Image
Sciences Institute, University Medical Center Utrecht,
Utrecht, Netherlands
Diffusion-weighted magnetic resonance imaging is prone
to large partial volume effects (PVEs) due to its large
voxel size. In this work, we studied the PVEs with
non-white matter (WM) tissue on estimation of the fiber
orientation distribution function (fODF) with
constrained spherical deconvolution (CSD). We found a
loss of precision in the detected fiber orientations and
an emergence of a high number of false orientations in
the fODF. The effects were most significant with gray
matter (GM) partial volume. We propose a modification to
CSD to further improve the estimation of the fODF
especially near the WM-GM interface.
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