Abstract #4505
Temperature-controlled Isotropic Diffusion Phantom with Wide Range of Apparent Diffusion Coefficients for Multicenter Assessment of Scanner Repeatability and Reproducibility
Michael A. Boss 1 , Thomas L. Chenevert 2 , John C. Waterton 3,4 , David M. Morris 4 , Hossein Ragheb 4 , Alan Jackson 4 , Nandita deSouza 5 , David J. Collins 5 , Bernard E. van Beers 6 , Philippe Garteiser 6 , Sabrina Doblas 6 , Stephen E. Russek 1 , Kathryn E. Keenan 1 , Edward F. Jackson 7 , and Gudrun Zahlmann 8
1
National Institute of Standards and
Technology, Boulder, CO, United States,
2
University
of Michigan, Ann Arbor, MI, United States,
3
AstraZeneca,
Macclesfield, United Kingdom,
4
University
of Manchester, Manchester, United Kingdom,
5
The
Institute of Cancer Research, Sutton, Surrey, United
Kingdom,
6
INSERM, France,
7
University
of Wisconsin, Madison, WI, United States,
8
F.
Hoffman-La Roche Ltd., Basel, Switzerland
We designed and built an ADC phantom to cover a wide
range of physiologically relevant ADC values. The
phantom used aqueous solutions of polyvinylpyrrolidone (PVP),
and we maintained constant temperature by filling the
phantom with ice water. The phantom was scanned at three
sites (1.5 and 3.0 T) to assess variability of ADC
measurement. We found excellent intrascanner
repeatability and good reproducibility across systems
and field strengths. There was non-negligible
variability only for the highest concentrations of PVP,
representing ADCs less than 0.3 x 10
-3
mm
2
/s.
The ADC of water at 0 °C was in excellent agreement
with literature values of 1.1 x 10
-3
mm
2
/s.
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