Abstract #4510
Visualizing complex white matter anatomy in the live monkey at 3T using super-resolution track density imaging
Louise Emsell 1,2 , Thijs Dhollander 2 , Koen Nelissen 3 , Ronald Peters 1,2 , Wim Vanduffel 3 , and Stefan Sunaert 1,2
1
Translational MRI, Imaging & Pathology, KU
Leuven & Radiology, University Hospitas Leuvenl, Leuven,
Belgium,
2
Medical
Imaging Research Center, Leuven, Belgium,
3
Laboratorium
voor Neuro-en Psychofysiologie, KU Leuven Medical
School, Leuven, Belgium
Visualising white matter anatomy in vivo at submilimetre
resolution using diffusion MRI is challenging without
access to high-field and strong gradient systems.
Short-tracks TDI (stTDI) is a post-processing technique
that allows super-resolution visualization beyond the
resolution of acquired data. In this pilot study we used
stTDI to enhance anatomical contrast in 3T monkey data
from 1.0mm3 to 0.25mm3 allowing the identification of
structures not visible on the 1.0mm3 colour FA maps
(e.g. stria medullaris, pre- and post-commissural
fornix, decussation of the superior cerebellar
peduncles). Reliability was assessed using bootstrapping
to model the effect of noise in the stTDI maps
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