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Abstract #4514

Quantification of voxel-wise total tract density: addressing the problems associated with track-count mapping

Fernando Calamante 1,2 , Robert Elton Smith 1 , J-Donald Tournier 1,3 , David Raffelt 1 , and Alan Connelly 1,2

1 The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia, 2 Department of Medicine, Austin Health and Northern Health, University of Melbourne, Melbourne, Victoria, Australia, 3 Centre for the Developing Brain, King's College London, London, United Kingdom

A biological parameter that would be valuable to draw from a DWI experiment is the local white matter axonal density. It has been suggested that track-density imaging (TDI) could provide such a measure; however, this has been the subject of controversy. The post-processing method of SIFT was recently introduced to minimise tractography biases. Importantly, the TDI intensity following SIFT ideally corresponds to the DC term of the FOD spherical harmonic expansion. We characterise the TDI reproducibility with and without SIFT pre-processing, as well as the reproducibility of DC maps, to determine the most appropriate method for quantifying voxel-wise fibre densities.

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