Sensitivity and specificity of prostate tumor discrimination by IVIM approximation
Gina Belmonte 1 , Vito Biondo 2 , Augusto La Penna 3 , Francesco Carbone 4 , Gianluca Vischi 5 , Leonardo Semeraro 5 , and Fabrizio Banci Buonamici 1
Medical Physics, University Hospital of
Siena, Siena, Italy, Italy,
of Siena, Italy, Italy,
University of Siena, Italy, Italy,
University Hospital of Siena, Italy, Italy,
University of Siena, Italy, Italy
We analyzed precision and accuracy in the discrimination
of prostate tumor of IVIM parameters measured with a
bi-exponential fit and a simplified approach, that
allows to estimate the diffusion coefficient and the
pseudo-diffusion fraction from a 2 b-values acquisition.
ROC analysis were used to extract the optimum cut-off
for each parameter that maximize the accuracy of test.
The simplified IVIM parameters are not accurate
estimates of the corresponding ones from the
bi-exponential fit, but discriminate prostate tumor from
healthy tissues in a accurate way. This simplified
technique allows therefore to reduce the acquisition
time and preserve a good diagnostic accuracy.
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