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Abstract #4543

Differential Diagnosis of Chest Lesions: Values of Diffusion-Weighted MR Imaging

Nan-Han Lu 1,2 , Tai-Been Chen 2 , Yung-Hui Huang 2 , Hueisch-Jy Ding 2 , Lee-Ren Yeh 1 , and Jeon-Hor Chen 1,3

1 Department of Radiology, E-DA Hospital, Kaohsiung, Kaohsiung, Taiwan, 2 Department of Medical Imaging and Radiological Sciences, I-Shou University, Kaohsiung, Kaohsiung, Taiwan, 3 Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, Irvin, CA, United States

Lung cancer is the leading cause of cancer death among men and women worldwide. The precise pre-operation diagnosis of chest neoplasms and inflammatory nodules using CT, MRI and PET-CT is difficult. The most sensitive diagnostic method is the surgical biopsy. The differences in imaging findings may reflect differences in histopathologic features of chest lesions. On T2-weighted MR images could not be used to distinguish malignant from benign pulmonary nodules. On diffusion-weighted MR imaging (DWI), the apparent diffusion coefficient (ADC) value refers to the specific diffusion capacity of a biologic tissue. ADC value depends largely on the presence of barriers to diffusion within the water microenvironment.The goal of this study is to present a novel method for differential diagnosis among primary chest cancers, metastatic tumors and benign tumors using ADC standard deviation value (SD) of diffusion-weighted MR imaging.

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