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Abstract #4549

Effects of gradient nonlinearity correction on DTI ADC and FA measurements for assessing breast cancer treatment response

David Newitt 1 , Ek Tsoon Tan 2 , Lisa Wilmes 1 , Hee Jung Shin 3 , Luca Marinelli 2 , and Nola Hylton 1

1 Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2 GE Global Research, Niskayuna, NY, United States, 3 Radiology, Asan Medical Center, University of Ulsan, Korea

Gradient nonlinearity (GN) is a significant source of error for quantitative diffusion MRI and is of particular concern in breast imaging where anatomy requires large offsets from magnet isocenter. GN correction (GNC) to correct for spatially-varying diffusion encoding was evaluated in DTI acquired ADC and FA of tumor and normal tissue regions in breast cancer subjects undergoing neoadjuvant chemotherapy. GNC resulted in a mean change in tumor ADC of -11% (range -4% to -19%), and in FA of -6% (range -24% to 20%). Percent change in tumor ADC between visits had an RMS change of 3% with GNC.

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