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Abstract #4574

Arterial Compliance of the Middle Cerebral Artery Measured with Short Inversion Time Pulsed Arterial Spin Labelling

Esther A.H. Warnert 1 , Judith E. Hall 2 , and Richard G. Wise 1

1 CUBRIC. School of Psychology, Cardiff University, Cardiff, United Kingdom, 2 Department of Anaesthetics and Intensive Care Medicine, School of Medicine, Cardiff University, United Kingdom

We investigate the possibility of using pulsed arterial spin labelling (PASL) to asses intracranial arterial compliance, a potential marker of cerebrovascular disease. To do so, we have acquired short inversion time PASL images (TI < 900ms) and retrospectively grouped these into systolic and diastolic phases of the cardiac cycle. Changes in arterial blood volume are calculated whilst taking the differences between label kinetics in systole and diastole into account that arise due to pulsatility of blood flow. Our results indicate that short inversion time PASL has the potential to assess arterial compliance of cerebral blood vessels.

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