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Abstract #4594

Bolus Arrival Time extraction using Super Temporal Resolution Analysis of DCE

Gilad Liberman 1,2 , Guy Nadav 1,3 , Yoram Louzoun 2,4 , Moran Artzi 1,5 , and Dafna Ben Bashat 1,5

1 Functional Brain Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2 Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel, 3 School of Electrical Engineering, Tel Aviv University, Tel Aviv, Israel, 4 Mathematics Department, Bar Ilan University, Ramat Gan, Israel, 5 Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

DCE is commonly acquired in a temporal-resolution of ~6sec, lower than inter-tissue differences (~1-3sec). This study proposes a super temporal-resolution analysis method for DCE, based on the Extended-Tofts Model (ETM) by including a delay accounting for the bolus arrival-time (BAT). The method was (1) tested on simulations (2) tested on data from patients with brain tumors, acquired with high(~2sec) and standard temporal-resolution and (3) BAT values were compared with DSC-TTP values. This study shows that accounting for the delay in DCE analysis, can result in a better AIF estimation and provides additional important parameter relating to the tissue vasculature.

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