Meeting Banner
Abstract #4596

Quantification of macromolecular albumin-Gd-DTPA contrast using 3D cardiac T1 mapping in normal myocardium

Vandoorne Katrien 1 , Moriel H Vandsburger 2 , Hagit Dafni 3 , Michal Neeman 4 , Gustav J Strijkers 1 , and Klaas Nicolay 1

1 Biomedical NMR, Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Physiology, University of Kentucky, Lexington, Kentucky, United States, 3 Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel, 4 Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

This pilot study aimed to develop a method to quantify the dynamics of a blood pool contrast agent for mapping the myocardial microvascular density and the rate of extravasation from blood vessels at the myocardium using in vivo dynamic contrast enhanced (DCE) MRI. Therefore, we quantify the characteristics and dynamics of the macromolecular contrast agent in blood vessels of control murine myocardium. In the future, this method could be used to quantify permeability in diseased myocardium. Therefore, this method using high-molecular weight contrast agent might allow quantification of permeability in the future and has the potential to determine disease progression.

This abstract and the presentation materials are available to members only; a login is required.

Join Here