Generalized Central Volume Principle for Recirculation with Contrast Elimination
Jeiran Jahani 1 , Glyn Johnson 1 , Valerij G Kiselev 2 , and Dmitry S Novikov 1
Bernard and Irene Schwartz Center for
Biomedical Imaging, Department of Radiology, New York
University School of Medicine, New York City, New York,
of Radiology, Medical Physics, University Medical Center
Freiburg, Freiburg, Germany
Quantitative perfusion analysis using bolus passage is
compromised by tracer recirculation. As an alternative
to the commonly used first bolus selection, we focus on
relating the recirculation boluses in the brain to the
topology and quantitative properties of the circulation
in the whole organism. The classical central volume
principle is generalized for the recirculation and the
presence of contrast elimination from the blood pool.
Our analytical approach makes use of treating each
organs response in the frequency domain, similar to
complex admittance in linear circuits. The simplest
among realistic models of circulation is selected
according to the data fitting quality.
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