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Abstract #4617

Amide proton transfer (APT) imaging of brain infection in children

hong zhang 1,2 , Xuna Zhao 3 , Jinyuan Zhou 2 , and Yun Peng 4

1 Imaging Center,Beijing Childrens Hospital, Capital Medical University, Beijing, Beijing, China, 2 Neurosection, Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3 Peking University, Beijing, China, 4 Beijing Childrens Hospital, Capital Medical University, Beijing, Beijing, China

APT-MRI is a chemical exchange saturation transfer (CEST) based approach in which the amide protons of endogenous proteins and peptides are irradiated to accomplish detection using the water signal. In this study, the APT approach was incorporated with standard brain MRI sequences and applied to children with brain infection at 3T. The initial results show that APT imaging can enhance the noninvasive identification of tissue heterogeneity in brain infection.

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