Abstract #4619
CEREBELLAR FUNCTIONAL CONNECTIVITY IN PATIENTS WITH PEDIATRIC MULTIPLE SCLEROSIS
Sara Cirillo 1 , Maria A. Rocca 1 , Paola Valsasina 1 , Pierangelo Veggiotti 2 , Lucia Moiola 3 , Angelo Ghezzi 4 , Giancarlo Comi 3 , Andrea Falini 5 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Child Neuropsychiatry Unit,
National Neurologic Institute "C. Mondino", Pavia, PV,
Italy,
3
Department
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy,
4
UO
Neurologia 2 - Centro Studi Sclerosi Multipla, Ospedale
di Gallarate, Gallarate, VA, Italy,
5
Department
of Neuroradiology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
We explored abnormalities of resting state (RS)
functional connectivity (FC) of the dentate nuclei (DN)
of the cerebellum in relapsing-remitting pediatric
multiple sclerosis (MS) patients and healthy controls
and whether these alterations correlate with clinical
and MRI measures of disease severity. In both groups, RS
FC of the R DN was significantly correlated with the FC
in other portions of the cerebellum, basal ganglia,
several regions in the prefrontal cortices and parietal
lobes. Compared to HC, patients experienced a
distributed pattern of reduced RS FC in multiple
regions, which was influenced by disease duration and
accumulation of white matter lesions.
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