Abstract #4632
Visualization of human brainstem substructures using gray matter nulling 3D-MPRAGE at 7Tesla
Michael Wyss 1 , Mike Bruegger 1,2 , Bernd Daeubler 3 , Laetitia Vionnet 1 , David Brunner 1 , and Klaas Pruessmann 1
1
Institute for Biomedical Engineering,
University of Zurich and ETH, Zurich, Zurich,
Switzerland,
2
Center
of Dental Medicine, University of Zurich, Zurich,
Switzerland,
3
Department
of Neuroradiology, University Hospital Zurich, Zurich,
Switzerland
The human brainstem and its substructures are known to
be involved in a multitude of functions. Incorporated
substructures are small and extremely densely packed,
resulting in low intrinsic contrast between these
structures. All this facets together hamper the
accurate, non-invasive visualization by in-vivo MR
imaging. This work describes the application of a
modified 3D-MPRAGE sequence at 7T in the human
brainstem. The use of an optimized high resolution
3D-MPRAGE sequence in the gray matter nulling regime at
7Tesla provides a clearly enhanced image contrast
between different substructures in the human brainstem,
which are nearly invisible with normal MR imaging.
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