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Abstract #4632

Visualization of human brainstem substructures using gray matter nulling 3D-MPRAGE at 7Tesla

Michael Wyss 1 , Mike Bruegger 1,2 , Bernd Daeubler 3 , Laetitia Vionnet 1 , David Brunner 1 , and Klaas Pruessmann 1

1 Institute for Biomedical Engineering, University of Zurich and ETH, Zurich, Zurich, Switzerland, 2 Center of Dental Medicine, University of Zurich, Zurich, Switzerland, 3 Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland

The human brainstem and its substructures are known to be involved in a multitude of functions. Incorporated substructures are small and extremely densely packed, resulting in low intrinsic contrast between these structures. All this facets together hamper the accurate, non-invasive visualization by in-vivo MR imaging. This work describes the application of a modified 3D-MPRAGE sequence at 7T in the human brainstem. The use of an optimized high resolution 3D-MPRAGE sequence in the gray matter nulling regime at 7Tesla provides a clearly enhanced image contrast between different substructures in the human brainstem, which are nearly invisible with normal MR imaging.

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