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Abstract #4664

Changes of leg- and hand-related corticospinal tract volumes during brain development

David O. Kamson 1,2 , Csaba Juhasz 1,2 , Harry T Chugani 1,2 , and Jeong-Won Jeong 1,2

1 Pediatrics and Neurology, Wayne State University, Detroit, Michigan, United States, 2 PET center, Children's Hospital of Michigan, Detroit, Michigan, United States

We estimated the streamline volume of the leg- and hand-related segments of the corticospinal tract (CST) in children between age 1 and 14 with or without neurological disease using a novel DTI technique. We found a steady decline of right hemispheric leg-related CST volumes with age, while there was no age-effect on the left hemispheric leg-related CST volume, or in either the left or right hand-related CST segments. Our findings are possibly a result of the gradual increase in the dominance of the left hemisphere.

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