Abstract #4664
Changes of leg- and hand-related corticospinal tract volumes during brain development
David O. Kamson 1,2 , Csaba Juhasz 1,2 , Harry T Chugani 1,2 , and Jeong-Won Jeong 1,2
1
Pediatrics and Neurology, Wayne State
University, Detroit, Michigan, United States,
2
PET
center, Children's Hospital of Michigan, Detroit,
Michigan, United States
We estimated the streamline volume of the leg- and
hand-related segments of the corticospinal tract (CST)
in children between age 1 and 14 with or without
neurological disease using a novel DTI technique. We
found a steady decline of right hemispheric leg-related
CST volumes with age, while there was no age-effect on
the left hemispheric leg-related CST volume, or in
either the left or right hand-related CST segments. Our
findings are possibly a result of the gradual increase
in the dominance of the left hemisphere.
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