Higher Striatal GABA Relates To A More Serial And Efficient Mode Of Action Cascading And Stronger Attentional Gating In Airplane Pilots
Shalmali Dharmadhikari 1,2 , Ali Yildiz 3 , Clara Quetscher 3 , Witold Chmielewski 3 , Ulrike Dydak 1,2 , and Christian Beste 4
School of Health Sciences, Purdue
University, W Lafayette, Indiana, United States,
of Radiology and Imaging Sciences, Indiana University
School of Medicine, Indianapolis, Indiana, United
for Cognitive Neuroscience, Biopsychology, Ruhr
University, Bochum, Germany,
Neurophysiology, Department of Child and Adolescent
Psychiatry, University of Dresden, Germany
A neurobiochemical-electrophysiological study was
conducted to examine the role of gamma-aminobutyric acid
(GABA) in the mechanism of action cascading, and hence
the mechanisms mediating superior multi-tasking
performance in airplane pilot trainees vs controls.
Airplane pilot trainees exhibited stronger coupling
leading to superior action control in situations
requiring a cascading of actions. The results indicate
that the speed of responding as well as attentional
gating functions depend on striatal GABA concentrations.
The results show that GABA is an important modulator of
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