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Abstract #4682

An Investigation into the Formation and Histology of Focal Basal Ganglia Mineralization with quantitative MRI

Andreas Glatz 1 , Lukas Pirpamer 2 , Christian Langkammer 2 , Maria C. Valds Hernndez 1 , Mark E. Bastin 1 , Joanna M. Wardlaw 1 , Franz Fazekas 2 , Reinhold Schmidt 2 , and Stefan Ropele 2

1 Brain Research Imaging Centre, University of Edinburgh, Edinburgh, Scotland, United Kingdom, 2 Department of Neurology, Medical University of Graz, Styria, Austria

Multifocal T2*-weighted hypointensities in the basal ganglia are linked to focal mineralization and have been proposed as a novel biomarker for microvascular disease and ageing. In this study we investigated the progression of basal ganglia T2*w hypointensities and the histology of the underlying tissue with quantitative MRI in a cohort of 300 community-dwelling subjects (183 females; 64 11 years) without history or signs of neuropsychiatric disorders. The results indicate a significant association of their volume with age and that they are linked to mostly aggregated and paramagnetic trace metals, which might be of vascular origin.

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